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31 Another RCT comparing metformin (500 mg twice daily) with a twice-daily capsule containing -lipoic acid, biotin, chromium polynicotinate, and zinc sulfate, showed significant ( P 6 months), higher doses (17002000 mg), and lower baseline weight were associated with higher efficacy of metformin for treatment of AN

First, niosomes improve the solubility and bioavailability of poorly water-soluble compounds such as QT, while also protecting labile drugs like LC from premature degradation in the gastrointestinal tract [122,123]

Animal evidence suggests this pathway also helps preserve lean mass during weight reduction, although the human data is still maturing

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